Study Shows CyberKnife® System Provides Long-Lasting Pain Relief for Trigeminal Neuralgia Patients
"This study is important because it reinforces that CyberKnife SRS provides unique benefits in the treatment of TN. Pain management goals were achieved and bothersome complications were rare even though a less invasive approach to delivering radiation was used," said Professor
TN is a disease often characterized by severe pain, with some patients describing it as the most atrocious pain human beings can suffer. Techniques like CyberKnife SRS may provide new hope for people living with this severe and challenging-to-treat medical condition.
Significant Pain Control
- Pain relief was achieved in 93.5 percent of patients after a median delay of three weeks after treatment
- Stable pain control was maintained by 76 percent of patients three years after the first treatment. The remainder of the patients attained pain control after a second treatment
Elimination of Pain Medication
- 78.9 percent of patients were completely pain- and medication-free within six months after treatment
- 93.5 percent of patients were able to decrease the dose of medications intended to control pain throughout follow-up and finally cease pain medication
- Overall, 18.1 percent of patients developed some sensory disturbance. Of these patients, 68 percent experienced the onset of complications after their second treatment; this is a typical side effect following re-irradiation
"The frameless CyberKnife Robotic Radiosurgery System delivers radiation beams from multiple unique angles (non-isocentric approach) with sub-millimeter accuracy. The reproducibility of the delivery technique resulted in excellent clinical outcomes for the patients with a non-invasive technique, unlike Gamma Knife. This study confirms the long lasting effect of one single fraction treatment delivered with the CyberKnife system," said Fabienne Hirigoyenberry-Lanson, PhD, Vice President Global Medical and Scientific Affairs, at
About Trigeminal Neuralgia
Trigeminal neuralgia is a chronic pain disorder affecting the trigeminal or 5th cranial nerve. The condition requires long-term medical treatment which usually starts with medications to lessen or block the pain signals sent to the brain. Over time some patients stop responding to medications or suffer from unpleasant side effects. For those patients, injections, surgery, or radiosurgery are alternative treatments.
About the Study
In this study, 138 patients with TN were treated with the CyberKnife System. A prescription dose of 60 Gy was delivered in a single fraction to a 6-mm segment of the nerve. The minimum and median follow-up was 36 and 52.4 months, respectively. All patients had taken medications for an average of 4.3 years before treatment with radiation. The primary study objective was to evaluate the safety and effectiveness of CyberKnife SRS in TN patients.
Important Safety Information
For Important Safety Information please refer to http://www.accuray.com/safety-statement.
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1 Young B, et al: Long-term outcome of high-dose Gamma Knife surgery in treatment of trigeminal neuralgia.
2 Regis J, et al: Long-term safety and efficacy of Gamma Knife surgery in classical trigeminal neuralgia: a 497-patient historical cohort study.
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