Accuray CyberKnife® System Provides Excellent Disease Control for Men with Recurrent Prostate Cancer, a Medical Condition with Few Viable Treatment Options
Hypofractionated radiation therapy involves the delivery of higher doses of radiation over a smaller number of treatment sessions, compared to conventional radiation therapy which requires a substantially longer course of treatment. SBRT uses advanced techniques to deliver ultra-hypofractionated radiation therapy — very high doses of radiation are administered over several days. This treatment process necessitates an extremely high degree of accuracy and precision. The CyberKnife System, designed to deliver SBRT, is the only radiotherapy device that can maintain sub-millimetric accuracy with continual imaging and automatic beam delivery corrections, including rotation, throughout treatment delivery, making it easier for clinicians to effectively treat patients while minimizing dose to healthy tissue.
Click here to see how the CyberKnife System treats prostate cancer.
"Men diagnosed with recurrent prostate cancer after previous radiation therapy have few treatment choices. Most, if treated, receive only ADT which has the potential for long-lasting 'whole body' side effects while rarely eradicating the tumor completely," said
Click here to learn about how Dr. Fuller uses the CyberKnife System in his practice.
The study titled, "Retreatment for Local Recurrence of Prostatic Carcinoma After Prior Therapeutic Irradiation: Efficacy and Toxicity of HDR-Like SBRT," evaluated 50 patients with biopsy-proven recurrent prostate cancer diagnosed at least two years after initial treatment. Forty-three patients had previously received treatment with conventionally fractionated radiation therapy and seven patients had received treatment with another method (five brachytherapy, one SBRT and one radical prostatectomy followed by post-prostate bed salvage radiation therapy). This study demonstrated:
- At five years, the disease-free survival (DFS) rate was 60 percent, indicating patients experienced no signs or symptoms of their cancer over that time period. This rate is within the reported range for salvage brachytherapy and comparable to reported salvage radical prostatectomy results, but without the need for hospitalization, anesthesia, and long recovery times typically associated with these treatments;
- The median prostate specific antigen (
PSA) decreased to 0.16 ng/mL at five years, similar to initial treatment with brachytherapy and lower than typical conventional fractionation, based on results from other studies;
- No grade two or higher gastrointestinal (GI) events were reported. Genitourinary (GU) toxicity was lower than reported rates for salvage radical prostatectomy and seems less frequent after prior standard external radiation treatment.
"This study is significant because it highlights a potential new option for extending symptom-free survival in men with locally recurrent prostate cancer previously treated with radiation therapy," said Fabienne Hirigoyenberry-Lanson, Ph.D., vice president global medical and scientific affairs, at
About the CyberKnife System
The CyberKnife System is the only robotic radiosurgery system that offers highly precise, non-surgical treatment for tumors and lesions anywhere in the body—including the brain, breast, kidney, liver, lung, pancreas, prostate and spine. The CyberKnife System tracks and automatically adapts for tumor or patient movement during treatment, delivering the radiation dose directly to the target with sub-millimeter precision. Synchrony® motion tracking and correction technology expands on the CyberKnife System's unique motion synchronization capabilities to provide additional precision when treating tumors that move with respiration. The high level of accuracy in dose delivery made possible by the system gives clinical teams the confidence to deliver state-of-the-art treatments for a wide range of cancers and functional disorders, without sacrificing patients' quality of life.
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Forward-looking statements speak only as of the date the statements are made and are based on information available to the company at the time those statements are made and/or management's good faith belief as of that time with respect to future events. The company assumes no obligation to update forward-looking statements to reflect actual performance or results, changes in assumptions or changes in other factors affecting forward-looking information, except to the extent required by applicable securities laws. Accordingly, investors should not put undue reliance on any forward-looking statements.
Public Relations Director, Accuray
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1 https://www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet#q6. Accessed 11/19/2019.
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