Data Published in The Lancet Oncology Indicate Men With Prostate Cancer Treated With the Accuray CyberKnife® Platform Experienced a Lower Incidence of Bladder Side Effects Than Those Treated With Conventional Linear Accelerators
- Latest research published in The Lancet Oncology: suggests bladder side effects were experienced half as often with CyberKnife SBRT as with conventional linear accelerator delivered SBRT two years after treatment
- Almost 20 years of global clinical data: shows the non-surgical CyberKnife platform provides excellent disease control with low rates of toxicity for men with prostate cancer
Chief Investigator Professor
"Radiotherapy can sometimes cause challenging bladder problems for men with prostate cancer, including passing urine more regularly and cystitis. These interesting new results suggest SBRT through CyberKnife can be delivered with similarly low levels of side effects as standard radiotherapy, which is typically given to patients over four to eight weeks, over a much shorter time period.
"So far, the findings from this study are promising and, over the next few years, we will analyze the long-term side effects and outcomes of SBRT. We hope this trial will eventually change practice and enable us to deliver curative treatment over fewer days, sparing patients numerous hospital visits."
In 2020, more than 1.4 million men worldwide were diagnosed with prostate cancer1. While it is typically a slow-growing and manageable disease, long-term treatment-related side effects can affect patients' physical and mental well-being for the rest of their lives. Technology that can minimize the risk of these side effects is key. The PACE data are noteworthy because they signal that men treated with CyberKnife SBRT are less likely to experience long-term side effects that can impact them over the course of their lives than men receiving conventional linear accelerator delivered SBRT.
SBRT treatments involve the delivery of very high doses of externally administered radiation over a small number of sessions, offering convenience for patients, compared with conventional radiation therapy which requires substantially more treatment sessions. In the PACE trial, SBRT was delivered in 5 sessions while conventional radiation therapy was delivered in 20 or 39 sessions.
"Clinicians using the CyberKnife® System pioneered prostate SBRT and are responsible for the publication of the vast majority of scientific studies on this treatment modality. The system is the only radiation therapy device supported by years of published clinical follow-up with a large number of patients, and these studies show that using the CyberKnife instead of conventional linear accelerators for prostate SBRT reduces significantly pain and urine frequency which have a real impact on daily activities," said
What makes the CyberKnife® System unique is that it is the only fully robotic radiation delivery system. The robotic design, coupled with real-time imaging, enables the system to deliver a maximum dose of radiation directly to the tumor from potentially thousands of unique angles with sub-millimeter precision. The system does this by using the
This capability is especially important when treating prostate cancer, because the prostate gland can move as much as 10 mm in as little as 30 seconds in an unpredictable manner, often caused by normal patient bodily functions such as filling of the bladder, gas in the bowel, or even slight patient movement during the procedure. In addition, the prostate is surrounded by sensitive organs and tissues.
About the PACE-B Trial
The PACE trial data provides level 1 clinical evidence – the strongest level of evidence on which to guide practice changes. PACE-B is a prospective, randomized trial conducted in 35 centers in the
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Public Relations Director, Accuray
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